The paper identifies a previously unrecognized cellular state with low transcriptomic complexity in mature tissues, linked to aging and cellular maintenance.

bioRxiv · Mar 25, 2026 · PreprintMolecular Biology

Cyclin A2 Induces Cytokinesis in Human Adult Cardiomyocytes and Drives Reprogramming in Mice

Esmaa Bouhamida, Sangeetha Vadakke Madathil, Prabhu Mathiyalagan, Amaresh Kumar Ranjan, Amir M Khan, Cherrie D. Sherman, Paul E. Miller, Andre Ghetti, Najah Abi‐Gerges, Hina W. Chaudhry

This study shows that Cyclin A2 induces cytokinesis in adult human cardiomyocytes and drives reprogramming in mice through transcriptomic analysis.

npj Regenerative Medicine · Nov 3, 2025Peer-reviewedCell Biology

Identification of the molecular components of enhancer-mediated gene expression variation in multiple tissues regulating blood pressure

Or Yaacov, Prabhu Mathiyalagan, Hanna Berk-Rauch, Santhi K. Ganesh, Luke Zhu, Thomas J. Hoffmann, Carlos Iribarren, NEIL J. RISCH, Dongwon Lee, Aravinda Chakravarti

The paper identifies genes regulating blood pressure by analyzing enhancer variants and integrating epigenomic data with genotype-phenotype associations across multiple tissues.

Hypertension · May 15, 2024Peer-reviewedGenetic & Genomic Medicine

Tissue-specific and tissue-agnostic effects of genome sequence variation modulating blood pressure

Dongwon Lee, Seong Kyu Han, Or Yaacov, Hanna Berk-Rauch, Prabhu Mathiyalagan, Santhi K. Ganesh, Aravinda Chakravarti

The paper identifies tissue-specific regulatory variants influencing blood pressure heritability using GWAS and gene expression data.

Cell Reports · Nov 1, 2023Peer-reviewedGenetics