Author
The University of Texas Health Science Center at HoustonORCID 0000-0002-6348-3359Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Supraja Kadagandla, Lavanya Gunamalai, Dongwon Lee, Ashish Kapoor
The paper identifies candidate causal cis-regulatory variants at electrocardiographic QT interval GWAS loci by integrating open chromatin data and expression quantitative trait loci.
Circulation Genomic and Precision Medicine · May 27, 2025Peer-reviewedGenetics
Dongwon Lee, Lavanya Gunamalai, Jeerthi Kannan, Kyla Vickery, Or Yaacov, Ana C. Onuchic-Whitford, Aravinda Chakravarti, Ashish Kapoor
The paper identifies functional enhancer variants at QT interval GWAS loci using MPRA and predicts their impact on cardiac gene expression.
bioRxiv · Mar 11, 2025 · PreprintGenetics
Lavanya Gunamalai, Parul Singh, Brian Berg, Leilei Shi, Ernesto Sanchez, Alexa Smith, Ghislaı̀n Breton, Mark T. Bedford, Darius Balciunas, Ashish Kapoor
The paper investigates the combined effects of SCN5A enhancer variants on gene expression and demonstrates their additive regulatory impact in vitro and in vivo.
Human Genetics and Genomics Advances · Sep 30, 2024Peer-reviewedGenetics