Darius Balciunas

EpicTope predicts and validates epitope tagging sites by analyzing structural and functional features, showing effectiveness in zebrafish proteins.

This study investigates the role of Tcf21 in zebrafish heart regeneration by knocking out its expression and observing reduced cardiomyocyte dedifferentiation and impaired regeneration.

The paper investigates the combined effects of SCN5A enhancer variants on gene expression and demonstrates their additive regulatory impact in vitro and in vivo.

The paper introduces a competitive dilution strategy to rapidly generate single-insertion transgenic zebrafish lines, reducing animal usage and improving reproducibility.

The paper develops a zebrafish CreERT2 driver line with a modified ubiquitin promoter that enables efficient tamoxifen-inducible recombination in embryos, larvae, and adults.

The paper develops a genetic method to distinguish genuine morpholino-induced phenotypes from those caused by off-target effects in zebrafish.

GeneWeld enables efficient and precise targeted integration in multiple species using CRISPR/Cas9 with minimal homology arms.

The paper describes a zebrafish gene break transposon library for genomic discovery and disease modeling, identifying novel gene expression patterns and generating models for human disease loci.