Characterization of Ataxia-linked MFN2 Variants Reveals a Lipid Droplet/Mitochondrial Axis Driving Ferroptosis
Mashiat Zaman, Armaan Mohan, Cole Chute, Fernanda Sousa Monteiro, Adriana Zardini Buzatto, Timothy E. Shutt
The paper identifies ataxia-linked MFN2 variants that increase ferroptosis susceptibility by enhancing fatty acid import from lipid droplets to mitochondria, leading to lipid peroxidation and cell death.
medRxiv · Sep 21, 2026 · PreprintGenetic & Genomic Medicine