The paper identifies age-stable and age-variable DNA co-methylation modules in whole-blood data from over 7,500 individuals, showing most modules remain stable with aging while a small subset undergoes reorganisation.

bioRxiv · Sep 18, 2026 · PreprintSystems Biology

Trans-eQTLs reveal the architecture of human gene regulatory networks

Robert Warmerdam, Harm-Jan Westra, Adriaan van der Graaf, Marc Jan Bonder, Patrick Deelen, Tijs van Lieshout, Anke Jannie Landman, Mihkel Jesse, Benjamin J. Strober, Toni A. Boltz, Sandra Lapinska, Sini Nagpal, Manke Xie, Darwin Tay, Holger Kirsten, , Habibul Ahsan

The paper maps cis- and trans-eQTLs in blood samples to infer gene regulatory networks and prioritize trait-relevant pathways.

medRxiv · Feb 5, 2026 · PreprintGenetic & Genomic Medicine

Trans-eQTL mapping prioritises USP18 as a negative regulator of interferon response at a lupus risk locus

Krista Freimann, Anneke Brümmer, Robert Warmerdam, Tarran S. Rupall, Ana Laura Hernández-Ledesma, Joshua Chiou, Emily Rose Holzinger, Joseph Maranville, Nikolina Nakić, Halit Ongen, Luca Stefanucci, Michael C. Turchin, eQTLGen, Habibul Ahsan, Philip Awadalla, , Suvi Rovio

The paper identifies USP18 as a negative regulator of interferon response at a lupus risk locus through trans-eQTL analysis in lymphoblastoid cell lines.

Nature Communications · Oct 2, 2025Peer-reviewedGenetic & Genomic Medicine

GWAS significance thresholds in large cohorts

Evans K. Cheruiyot, Tingyan Yang, Allan F. McRae

This study determines updated GWAS significance thresholds for large cohorts, finding that a stricter p-value threshold reduces false positives in studies including rare variants.

bioRxiv · Dec 9, 2024 · PreprintGenetics

Species-informative SNP markers for characterising freshwater prawns of genus Macrobrachium in Cameroon

Judith Georgette Makombu, Evans K. Cheruiyot, Francesca Stomeo, David Thuo, Pius Mbu Oben, Benedicta Oshuware Oben, Paul Zango, Eric Mialhe, Jules Romain Ngueguim, Fidalis D. N. Mujibi

This study develops a 72-SNP panel for accurately distinguishing Macrobrachium species in Cameroon using allele frequency, Fst, and PCA analyses.

bioRxiv · Jan 24, 2022 · PreprintGenomics

New loci and neuronal pathways for resilience to heat stress in animals

Evans K. Cheruiyot, M. Haile‐Mariam, Benjamin G. Cocks, Iona M. MacLeod, Ruidong Xiang, J.E. Pryce

This study identifies new genetic loci and neuronal pathways associated with heat tolerance in dairy cows using genome-wide association analysis of milk production traits.

Scientific Reports · Aug 17, 2021Peer-reviewedGenomics