Darwin Tay

Malassezia and the Asian menopausal skin

This study investigates how menopause alters Malassezia fungal populations on skin and their impact on inflammation and skin health in Asian women.

Trans-eQTLs reveal the architecture of human gene regulatory networks

The paper maps cis- and trans-eQTLs in blood samples to infer gene regulatory networks and prioritize trait-relevant pathways.

Coronary Artery Disease Risk Variant rs6903956 Links to Endothelial Dysfunction via PHACTR1 Regulation

This study identifies rs6903956 as a CAD risk variant that regulates endothelial dysfunction through PHACTR1 and EDN1 expression via HOXA4 and MEIS1 binding.

Nuclear regulatory disturbances precede and predict the development of Type-2 diabetes in Asian populations

The paper identifies DNA methylation biomarkers predictive of Type-2 diabetes in Asian populations and shows their utility in risk stratification.

Epigenome-wide association study for dilated cardiomyopathy in left ventricular heart tissue identifies putative gene sets associated with cardiac development and early indicators of cardiac risk

This study identifies 194 epigenome-wide significant CpGs associated with dilated cardiomyopathy (DCM) and links them to cardiac gene expression and cardiovascular risk factors.

Metabolome-wide association of carotid intima media thickness identifies FDX1 as a determinant of cholesterol metabolism and cardiovascular risk in Asian populations.