Anneke Brümmer

Trans-eQTL mapping prioritises USP18 as a negative regulator of interferon response at a lupus risk locus

The paper identifies USP18 as a negative regulator of interferon response at a lupus risk locus through trans-eQTL analysis in lymphoblastoid cell lines.

Ribosomal modification by BUD23 drives selective translational control over energy state and metabolic health

This study identifies BUD23 as a regulator of energy homeostasis by controlling translation of mitochondrial and lipogenic mRNAs, linking ribosomal modification to metabolic health.

Pus7 mutation links tRNA dysregulation to aggressive behavior through activation of the integrated stress response and glycolytic reprogramming

The paper shows that Pus7 mutations reduce tRNA-Asp levels, activating the integrated stress response and glycolytic reprogramming, which contributes to aggressive behavior.

Disentangling genetic effects on transcriptional and post-transcriptional gene regulation through integrating exon and intron expression QTLs

This study integrates exon and intron expression QTLs to disentangle genetic effects on transcriptional and post-transcriptional gene regulation, revealing shared and distinct cis-QTLs and their implications for GWAS colocalization.

Analysis of eukaryotic lincRNA sequences reveals signatures of repressed translation in species under strong selection

The paper analyzes lincRNA sequences across six eukaryotes to identify sequence signatures of repressed translation, finding shorter ORFs and suboptimal codon usage in species under strong selection.