High-Parameter Spatial Multi-Omics through Histology-Anchored Integration
Yonghao Liu, Chuyao Wang, Zhikang Wang, Liang Chen, Zhi Li, Jiangning Song, Qi Zou, Rui Gao, Bin‐Zhi Qian, Xiaoyue Feng, Renchu Guan, Zhiyuan Yuan
This paper introduces SpatialEx and SpatialEx+ frameworks to integrate spatial multi-omics data using histology as an anchor, achieving high-parameter co-profiling across tissue sections.
Nature Methods · Dec 17, 2025Peer-reviewedBioinformatics