Author

Liang Chen

Shantou UniversityORCID 0000-0001-6644-477XUnclaimed ORCID profile · follow to get notified of new preprints

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Liang Chen20 papers · Pacific Northwest National Laboratory

Biology Disciplines

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Bioinformatics· 3

Signature Assays, Organisms & Methods

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Approach:contrastive learning· 2 Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:whole-genome sequencing· 2 Research Focus:batch correction / integration· 1 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Bin‐Zhi QianiD· 1 shared Chuyao WangiD· 1 shared Fuhu Song· 1 shared Huiyan SuniD· 1 shared Jiangning SongiD· 1 shared Qi ZouiD· 1 shared Qingyang YiniD· 1 shared Renchu GuaniD· 1 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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1 shared paperBioinformatics

Bin‐Zhi QianORCID

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3 papers

Recent·Most cited

BioinformaticsNature MethodsPeer-reviewedDec 17, 2025

High-Parameter Spatial Multi-Omics through Histology-Anchored Integration

Yonghao Liu, Chuyao Wang, Zhikang Wang…·Zhiyuan Yuan

This paper introduces SpatialEx and SpatialEx+ frameworks to integrate spatial multi-omics data using histology as an anchor, achieving high-parameter co-profiling across tissue sections.

26 citationstop 1%

spatial transcriptomicswhole-genome sequencing

𝕏 PostBluesky

BioinformaticsbioRxivPreprintApr 28, 2025

Interpretable neural networks prioritize cancer driver genes from genome-wide dependency landscapes

Qingyang Yin, Liang Chen

The paper introduces two interpretable neural networks to prioritize cancer driver genes by analyzing genome-wide dependency landscapes and drug-response patterns.

1 citation

humanwhole-genome sequencing

𝕏 PostBluesky

BioinformaticsbioRxivPreprintJan 18, 2021

DBPOM: a comprehensive database of pharmaco-omics for cancer precision medicine

Yijun Liu, Fuhu Song, Zhi Li…·Yi Chang

DBPOM is a database that integrates pharmaco-omics data to estimate drug effectiveness and adverse effects for cancer patients by mapping cell lines to individuals based on genetic similarities.

1 citation

humanbulk RNA-seq

𝕏 PostBluesky