Thierry Fest

Regulus infers signed transcriptional regulatory networks from few samples by integrating TF binding, gene expression, and regulatory region data with biological constraints.

The paper analyzes reproducibility issues in the Regulatory Circuits project and proposes solutions for improving reusability and reproducibility of its data integration pipeline.

The paper shows that locus suicide recombination (LSR) occurs in human B-cells during activation, targeting the IgH locus and leading to cell death.