Emilie Lereclus

This paper develops a 3D artificial marrow organoid model to study NK and myeloid cell differentiation, showing improved immune receptor expression and drug response compared to 2D models.

This study identifies five plasma cell subsets in humans and mice, showing their heterogeneity is driven by immune challenge type and B cell origin.

The paper shows that locus suicide recombination (LSR) occurs in human B-cells during activation, targeting the IgH locus and leading to cell death.