AdSI-MIMO: Adaptive stain imputation with multi-input and multi-output learning for multiplex immunofluorescence imaging
Xingnan Li, Priyanka Rana, Tuba Nur Gide, Nurudeen Adedayo Adegoke, Yizhe Mao, Shlomo Berkovsky, Enrico W Coiera, James S. Wilmott, Sidong Liu
AdSI-MIMO improves stain imputation for multiplex immunofluorescence images by generating multiple biomarker outputs from varied input combinations, achieving better performance for CD8 and PD-L1 imputation.
bioRxiv · Jun 27, 2025 · PreprintBioinformatics