Cancer Biologynpj Systems Biology and ApplicationsPeer-reviewed
Simulating BRAFV600E-MEK-ERK signalling dynamics in response to vertical inhibition treatment strategies
Alice De Carli, Yury Kapelyukh, Jochen Kursawe…·S. J. HAMIS
This paper develops a mathematical model of BRAFV600E-MEK-ERK signaling dynamics to simulate responses to vertical inhibition treatment strategies and identify effective combinations.