Ligia Assumpção Papale

The paper presents a multi-omics atlas of myelomeningocele in sheep, identifying heritable genetic and epigenetic factors and shared biological pathways across tissues.

The paper identifies differentially methylated genes in blood samples of individuals with mild cognitive impairment and Alzheimer's disease compared to cognitively unimpaired controls.

The paper identifies differentially methylated nuclear genes encoding mitochondrial proteins in blood samples from individuals with mild cognitive impairment and Alzheimer's disease compared to cognitively unimpaired controls.

The paper identifies sex-specific DNA methylation differences in blood samples from individuals with mild cognitive impairment and Alzheimer's disease, showing distinct epigenetic regulation by sex.

This study examines the relationship between telomere length and cognitive function in underrepresented middle-aged and older adults, finding preliminary evidence of an independent association with chronological age.

The paper uses whole genome methylation sequencing in blood samples to identify differentially methylated positions associated with cognitive status in mild cognitive impairment and Alzheimer's disease.

The paper shows that prenatal stress in Cntnap2 heterozygous mice disrupts 5hmC levels and alters gene expression, leading to neurodevelopmental behaviors similar to knockout mice.