Sterling C. Johnson

Genetic architecture of the limbic white matter microstructure in aging and Alzheimer's Disease.

This study identifies genetic loci and pathways associated with limbic white matter microstructure in aging and Alzheimer's Disease using multi-cohort diffusion MRI and bulk RNA-seq data.

Gut bacterial metabolite imidazole propionate potentiates Alzheimer's disease pathology

This study identifies imidazole propionate as a gut bacterial metabolite linked to Alzheimer's disease pathology through human and mouse experiments.

Predicting Autopsy-Confirmed Neuropathology across Clinical, Neuroimaging, and CSF Biomarkers using Machine Learning

The paper uses machine learning to predict autopsy-confirmed neuropathology from clinical, neuroimaging, and CSF biomarkers, finding that different modalities best predict specific pathologies.

Evaluation of Deep Learning Algorithms to Predict Multiple Dementia-Related Neuropathologies from Brain MRI, Clinical and Genetic Data

This study evaluates deep learning models that predict multiple dementia-related neuropathologies using MRI, clinical, and genetic data, showing the potential of multimodal AI for non-invasive profiling.

Sex-Specific Genetic Drivers of Memory, Executive Functioning, and Language Performance in Older Adults

The paper identifies sex-specific genetic loci associated with memory, executive functioning, and language performance in older adults through genome-wide meta-analyses.

Sex-Specific Differential DNA Methylation in Mild Cognitive Impairment and Alzheimers Disease

The paper identifies sex-specific DNA methylation differences in blood samples from individuals with mild cognitive impairment and Alzheimer's disease, showing distinct epigenetic regulation by sex.

Telomere length and cognitive function among middle-aged and older participants from communities underrepresented in aging research: A preliminary study

This study examines the relationship between telomere length and cognitive function in underrepresented middle-aged and older adults, finding preliminary evidence of an independent association with chronological age.

Evaluating the association of APOE genotype and cognitive resilience in SuperAgers

This study examines the association between APOE genotype and cognitive resilience in SuperAgers, finding lower APOE-ε4 and higher APOE-ε2 frequencies in non-Hispanic White SuperAgers compared to controls and Alzheimer's cases.

Whole genome methylation sequencing in blood from persons with mild cognitive impairment and dementia due to Alzheimer's disease identifies cognitive status

The paper uses whole genome methylation sequencing in blood samples to identify differentially methylated positions associated with cognitive status in mild cognitive impairment and Alzheimer's disease.

Sex, racial, and APOE-ϵ4 allele differences in longitudinal white matter microstructure in multiple cohorts of aging and Alzheimer's disease

The paper examines how sex, race, and APOE-ε4 allele status affect white matter microstructure across multiple aging and Alzheimer's disease cohorts.

Biobank-wide association scan identifies risk factors for late-onset Alzheimer's disease and endophenotypes

The paper uses BADGERS to identify risk factors and endophenotypes for late-onset Alzheimer's disease by analyzing biobank-wide data.

Neuropathology-based APOE genetic risk score better quantifies Alzheimer's risk

The paper develops an APOE genetic risk score based on neuropathology that better explains CSF biomarker variance than traditional APOE ε4 metrics.

Novel genomic loci and pathways influence patterns of structural covariance in the human brain

The paper identifies 617 novel genomic loci and pathways associated with structural covariance patterns in the human brain using a stochastic multivariate factorization method.

Cerebrospinal fluid metabolomics identifies 19 brain-related phenotype associations

The paper performs a metabolome-wide association study to identify CSF metabolite-phenotype associations in neurological and psychiatric disorders.

Metabolites associated with early cognitive changes implicated in Alzheimer’s disease

The paper identifies seven metabolites associated with executive function decline in early Alzheimer’s disease using longitudinal plasma samples from the WRAP cohort.

CSF metabolites associate with CSF tau and improve prediction of Alzheimer's disease status

The paper identifies CSF metabolites associated with tau levels and shows they improve prediction of Alzheimer's disease status.

Proper names from story recall are associated with beta-amyloid in cognitively unimpaired adults at risk for Alzheimer's disease

The paper investigates if story recall of proper names is linked to beta-amyloid levels in cognitively unimpaired adults at risk for Alzheimer's disease, finding an association with delayed recall.

Self-reported health behaviors and longitudinal cognitive performance: Results from the Wisconsin Registry for Alzheimer’s Prevention

This study examines the association between multiple self-reported health behaviors and cognitive decline in a cohort of non-demented middle-aged individuals, finding limited significant associations.

Amyloid duration is associated with preclinical cognitive decline and tau PET

This study uses longitudinal amyloid PET data to estimate amyloid chronicity and finds it is linked to cognitive decline and tau burden in preclinical Alzheimer's disease.

Harmonization of large multi-site imaging datasets: Application to 10,232 MRIs for the analysis of imaging patterns of structural brain change throughout the lifespan

The paper harmonizes 10,232 structural brain MRIs from 18 studies to create a normative reference of brain development and aging across 3 to 96 years.

Integrated analysis of genomics, longitudinal metabolomics, and Alzheimer’s risk factors among 1,111 cohort participants

The paper integrates genomics, metabolomics, and Alzheimer’s risk factors from 1,111 participants to identify gene-metabolite-AD risk factor relationships and metabolites explaining tau variance.

Longitudinal plasma metabolomics of aging and sex

This study identifies age and sex-associated metabolite trajectories in longitudinal plasma samples from the WRAP cohort, revealing sex-specific changes in metabolites like sphingolipids and heritability patterns.

Characterizing the effects of sex, APOE ɛ4, and literacy on mid-life cognitive trajectories: Application of Information-Theoretic model-averaging and multi-model inference techniques to the Wisconsin Registry for Alzheimer’s Prevention Study

The paper uses information-theoretic model-averaging to analyze cognitive decline factors in mid-life, finding sex, literacy, and APOE ɛ4 effects with varying impacts.

Longitudinal standards for mid-life cognitive performance: Identifying abnormal within-person changes in the Wisconsin Registry for Alzheimer’s Prevention

The paper develops longitudinal standards for mid-life cognitive performance using quantile regression to identify abnormal within-person changes and their associations with clinical outcomes.

In vivo characterization and quantification of neurofibrillary tau PET radioligand 18F-MK-6240 in humans from Alzheimer’s disease dementia to young controls

This paper evaluates the in vivo kinetics and quantification of the tau PET radioligand [18F]MK-6240 in humans across Alzheimer’s disease stages and controls.

Age-accelerated cognitive decline in asymptomatic adults with CSF β-amyloid

The paper compares cognitive and hippocampal volume decline in asymptomatic adults with and without CSF β-amyloid or tau markers, finding accelerated decline in those with positive markers.

Modifiable risk factors moderate the relationship between amyloid and cognition in midlife

This study shows that hypertension and depression, but not obesity, moderate the link between amyloid and cognitive decline in midlife individuals at risk for Alzheimer's disease.

The Wisconsin Registry for Alzheimer’s Prevention: A Review of findings and current directions

The paper reviews findings from the Wisconsin Registry for Alzheimer’s Prevention, highlighting associations between genetic and lifestyle factors and early AD pathophysiology.

Temporal order of Alzheimer’s disease-related cognitive marker changes in BLSA and WRAP longitudinal studies

The paper uses longitudinal data to identify the temporal order of cognitive marker changes in Alzheimer’s disease, finding that digit span tests decline earliest followed by verbal memory and other tests.