Spatial proteomics and transcriptomics of placenta accreta spectrum
Helena C. Bartels, Sodiq Hameed, Constance Young, Myriam Nabhan, Paul Downey, Kathleen M. Curran, Janet McCormack, Aurélie Fabre, Walter Kölch, Vadim Zhernovkov, Donal J. Brennan
This study uses spatial transcriptomics and proteomics to identify dysregulated genes and proteins in placenta increta, revealing ECM degradation, immune suppression, and epithelial-mesenchymal transition promoting trophoblast invasion.
bioRxiv · Mar 21, 2024 · PreprintBioinformatics