Author

Donal J. Brennan

University College DublinORCID 0000-0002-6747-3342Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1

Frequent Co-Authors

Vadim ZhernovkoviD· 3 shared Walter KölchiD· 3 shared Aurélie FabreiD· 2 shared Janet McCormackiD· 2 shared Ann D. Treacy· 1 shared Constance Young· 1 shared Daniel C. LiebleriD· 1 shared Donagh EganiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersBioinformatics

Vadim ZhernovkovORCID

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3 papers

Recent·Most cited

Cancer Biologynpj Precision OncologyPeer-reviewedJun 16, 2025

A TEMPORAL MODEL OF TUMOR-IMMUNE DYNAMICS IN HIGH GRADE SEROUS OVARIAN CANCER

Donagh Egan, Kate Glennon, Ann D. Treacy…·Donal J. Brennan

This study uses proteomics and immunohistochemistry to analyze tumor-immune dynamics in HGSOC, identifying mechanisms of immune escape across metastatic progression.

7 citations

humanproteomics

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BioinformaticsbioRxivPreprintApr 16, 2024

Physical cell-cell interactions regulate transcriptional programmes that control the responses of high grade serous ovarian cancer patients to therapy.

Sodiq Ayobami Hameed, Walter Kölch, Donal J. Brennan, Vadim Zhernovkov

The paper identifies transcriptional changes from physical cell-cell interactions that predict ovarian cancer patient responses to therapy.

3 citations

humanscRNA-seq

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BioinformaticsbioRxivPreprintMar 21, 2024

Spatial proteomics and transcriptomics of placenta accreta spectrum

Helena C. Bartels, Sodiq Hameed, Constance Young…·Donal J. Brennan

This study uses spatial transcriptomics and proteomics to identify dysregulated genes and proteins in placenta increta, revealing ECM degradation, immune suppression, and epithelial-mesenchymal transition promoting trophoblast invasion.

2 citations

humanspatial transcriptomics

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