Repeated administration of pharmaceutical-grade medium chain triglycerides, a common pharmacologic excipient, confers dose-dependent toxicity by the intraperitoneal but not oral route in mice
Mitzi Adler-Wachter, Julia Tsai, Brendan Schweitzer, Ashley McDonough, Jessica M. Snyder, Melissa L. Barker‐Haliski, Jonathan R. Weinstein
This study shows that repeated intraperitoneal administration of pharmaceutical-grade MCTs causes dose-dependent toxicity and mortality in mice, while oral administration does not.
Journal of the American Association for Laboratory Animal Science · Jun 18, 2025Peer-reviewedPharmacology & Toxicology