Melissa L. Barker‐Haliski

The paper investigates how pregnancy history and PSEN2 deficiency affect cognitive function and neurobiology in aged female mice, finding no synergistic effects.

This study uses a humanized mouse model to show that antisense oligonucleotides reduce seizure activity and mortality in DRPLA.

This paper demonstrates that antisense oligonucleotides targeting human ATN1 protect against DRPLA pathology in a fully humanized mouse model.

This study shows that loss of presenilin 2 function increases seizure susceptibility in young mice but not in aged mice, and reduces GluK5 expression in aged PSEN2 knockout mice.

The paper introduces a framework to evaluate preclinical seizure models' predictive validity for clinical focal onset seizures and identifies three models with high predictive validity.

This study shows that repeated intraperitoneal administration of pharmaceutical-grade MCTs causes dose-dependent toxicity and mortality in mice, while oral administration does not.

This study investigates how antibiotic-induced gut dysbiosis affects hippocampal glial responses and neuropathology after TMEV infection, showing region-specific effects and potential neuroprotective effects of CBZ.

This study shows that antibiotic-induced gut dysbiosis alters seizure burden and carbamazepine anticonvulsant activity in a Theiler's virus encephalitis model without affecting drug plasma concentrations.

This study examines the acute dose-related effects of antiseizure medicines on behavior in rats with epilepsy, finding varying impacts on locomotion and exploration.

This study investigates how Alzheimer's disease-associated genotypes affect seizure outcomes and antiseizure medication efficacy in aged mice, finding differential responses to specific drugs.

This study examines how diet and sterilization affect gut microbiome diversity and acute seizure incidence in TMEV-infected mice, finding diet impacts seizure frequency and behavioral outcomes.

This study shows chronic seizures worsen cognitive deficits in aged female PSEN2 KO mice but not males, with sex-specific changes in neuroinflammation and neuroplasticity.

This study shows that chronic seizures in pre-symptomatic APP/PS1 mice worsen Alzheimer's disease-related pathology and serotonin pathway disruptions without amyloid β plaque formation.

This paper introduces a novel mouse model of sustained seizure emergency with distinct pharmacological, electrographic, and pathological features compared to status epilepticus.

This paper describes a moderate-throughput drug screening platform in a rat model of temporal lobe epilepsy to evaluate antiepileptogenic agents, finding no significant effect of everolimus or phenobarbital on preventing spontaneous recurrent seizures.