Author

Fernando Lehue

University of ValparaísoORCID 0000-0002-6502-3487Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 4

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Organism:human· 3 Research Focus:benchmarking· 2 Assay:electronic health records· 2 Assay:imaging· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Carlos Coronel‐OliverosiD· 4 shared Enzo TagliazucchiiD· 4 shared Patricio OrioiD· 4 shared Vicente MedeliD· 3 shared Agustín M. IbáñeziD· 2 shared Iván MindliniD· 2 shared Josephine CruzatiD· 2 shared Natalia Kowalczyk‐GrębskaiD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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4 shared papersNeuroscience

Carlos Coronel‐OliverosORCID

Mutual co-authors in cluster

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4 papers

Recent·Most cited

Structural determinants of dynamical state transitions in disorders of consciousness: a whole-brain modeling approach

Fernando Lehue, Iván Mindlin, Carlos Coronel‐Oliveros, Enzo Tagliazucchi, Patricio Orio, Jacobo Diego Sitt

This study uses whole-brain modeling to show that structural brain hubs influence dynamical state transitions in disorders of consciousness.

bioRxiv · Jul 1, 2026 · PreprintNeuroscience

A multi-frequency whole-brain neural mass model with homeostatic feedback inhibition

Carlos Coronel‐Oliveros, Fernando Lehue, Ruben A Herzog, Iván Mindlin, Marilyn Gatica, Natalia Kowalczyk‐Grębska, Vicente Medel, Josephine Cruzat, Raúl González-Gómez, Hernán Hernandez, Enzo Tagliazucchi, Pavel Prado, Patricio Orio, Agustín M. Ibáñez

This paper introduces a modified neural mass model with inhibitory synaptic plasticity to better simulate EEG and fMRI recordings during NREM sleep and capture the spectral richness of brain activity.

PLoS Computational Biology · May 13, 2026Peer-reviewedNeuroscience

Noradrenaline and Acetylcholine shape Functional Connectivity organization of NREM substages: an empirical and simulation study

Fernando Lehue, Carlos Coronel‐Oliveros, Vicente Medel, Thomas Liebe, Jörn Kaufmann, Sebastián Orellana, Diego Becerra, Enzo Tagliazucchi, Patricio Orio

This study investigates how noradrenaline and acetylcholine influence functional connectivity during NREM sleep stages using a whole brain model and empirical data.

PLoS Computational Biology · Oct 28, 2025Peer-reviewedNeuroscience

Gaming expertise induces meso-scale brain plasticity and efficiency mechanisms as revealed by whole-brain modeling

Carlos Coronel‐Oliveros, Vicente Medel, Sebastián Orellana, Julio Rodiño, Fernando Lehue, Josephine Cruzat, Enzo Tagliazucchi, Aneta Brzezicka, Patricio Orio, Natalia Kowalczyk‐Grębska, Agustín M. Ibáñez

This study uses a whole-brain model to show that video game expertise is linked to meso-scale functional connectivity changes and improved noise filtering in brain networks.

NeuroImage · May 2, 2024Peer-reviewedNeuroscience