HINS: HLA-mediated immunogenic neoantigen score for robust prediction of immune checkpoint blockade response
Qiang Yang, Long Xu, Weihe Dong, Xiaokun Li, Kuanquan Wang, Suyu Dong, Gongning Luo, Xianyu Zhang, Tiansong Yang, Xin Gao, Guohua Wang
This paper introduces HINS, a deep-learning method that predicts immune checkpoint blockade response using HLA-mediated immunogenic neoantigen scores, achieving high accuracy in identifying responders.
bioRxiv · Dec 12, 2025 · PreprintBioinformatics