Author

Xianyu Zhang

Third Affiliated Hospital of Harbin Medical UniversityORCID 0000-0002-9738-2361Unclaimed ORCID profile · follow to get notified of new preprints

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XianYu Zhang1 paper

Biology Disciplines

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Bioinformatics· 2

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:benchmarking· 1 Research Focus:gene regulatory network inference· 1 Assay:proteomics· 1 Approach:transformer / foundation model· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Gongning LuoiD· 2 shared Guohua WangiD· 2 shared Kuanquan WangiD· 2 shared Long XuiD· 2 shared Qiang YangiD· 2 shared Suyu DongiD· 2 shared Tiansong YangiD· 2 shared Weihe DongiD· 2 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBioinformatics

Gongning LuoORCID

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2 papers

Recent·Most cited

BioinformaticsbioRxivPreprintDec 12, 2025

HINS: HLA-mediated immunogenic neoantigen score for robust prediction of immune checkpoint blockade response

Qiang Yang, Long Xu, Weihe Dong…·Guohua Wang

This paper introduces HINS, a deep-learning method that predicts immune checkpoint blockade response using HLA-mediated immunogenic neoantigen scores, achieving high accuracy in identifying responders.

DOI 10.64898/2025.12.09.693330

humanwhole-genome sequencing

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BioinformaticsPLoS Computational BiologyPeer-reviewedSep 12, 2025

THLANet: A Deep Learning Framework for Predicting TCR-pHLA Binding in Immunotherapy Applications

Long Xu, Qiang Yang, Weihe Dong…·Guohua Wang

THLANet predicts TCR-pHLA binding using deep learning, outperforming existing methods and providing structural insights into TCR-antigen interactions.

8 citations

humanproteomics

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