Author

Jie Lyu

University of California, IrvineORCID 0000-0002-6530-5257Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 2

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Assay:scRNA-seq· 1 Research Focus:trajectory inference· 1

Frequent Co-Authors

Fanglue PengiD· 1 shared Fei XuiD· 1 shared Gen YangiD· 1 shared Hai LiniD· 1 shared Huan HuiD· 1 shared Jianwei ShuaiiD· 1 shared Jianzhong SuiD· 1 shared Jingyi Jessica LiiD· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBioinformatics

Fanglue PengORCID

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2 papers

Recent·Most cited

BioinformaticsNucleic Acids ResearchPeer-reviewedApr 18, 2024

SCTC: inference of developmental potential from single-cell transcriptional complexity

Hai Lin, Huan Hu, Zhen Feng…·Jianwei Shuai

This paper introduces SCTC, a metric for inferring single-cell developmental potential from scRNA-seq data, showing it outperforms gene diversity metrics.

7 citations

scRNA-seqstatistical model

𝕏 PostBluesky

BioinformaticsScience AdvancesPeer-reviewedNov 11, 2020

DORGE: Discovery of Oncogenes and Tumor SuppressoR Genes Using Genetic and Epigenetic Features

Jie Lyu, Jingyi Jessica Li, Jianzhong Su…·Wei Li

DORGE identifies cancer driver genes by integrating genetic and epigenetic data, finding histone modifications predict TSGs and missense mutations predict OGs.

63 citations

humanDNA methylation

𝕏 PostBluesky