Fanglue Peng

This study shows that GPCR-Ga13 signaling is essential for intestinal IEL survival by enabling migration to cytokine-rich niches, with loss of G13 leading to impaired function and increased disease severity.

The paper shows that mite-induced migratory CD103+ skin ILC2s enter the lung, become resident, and alter lung immunity by changing immune response trajectories.

This paper performs in vivo CRISPR screens in human T cells to identify genetic modifiers of T cell function in solid tumors, finding P2RY8-G13 and GNAS as key regulators.

The paper re-evaluates differential expression methods on semi-synthetic RNA-seq data without normalization, finding the Wilcoxon rank-sum test still outperforms dearseq in FDR control and power.

The paper shows that popular differential expression methods like DESeq2 and edgeR have high false discovery rates in population-level RNA-seq data, recommending the Wilcoxon rank-sum test instead.

The paper identifies an atlas of 3QTLs associated with alternative polyadenylation across 46 tissues, showing they explain 16.1% of trait-associated variants and contribute to disease independently of gene expression.

DORGE identifies cancer driver genes by integrating genetic and epigenetic data, finding histone modifications predict TSGs and missense mutations predict OGs.