Age-linked suppression of lipoxin A4 mediates cognitive deficits in mice and humans
Fabrício A. Pamplona, Gabriela Vitória, Felipe Campos Ribeiro, Carolina A. Moraes, Pítia Flores Ledur, Karina Karmirian, Isis Moraes Ornelas, Luciana M. Leo, Bruna da Silveira Paulsen, Felipe Kenji Sudo, Gabriel Coutinho, Cláudia Drummond, Naima Assunção, Bart Vanderborght, Claudio de Azevedo Canetti, , Fernanda Freire Tovar-Moll
This study shows that reduced lipoxin A4 levels in aging brains contribute to cognitive deficits in mice and humans, suggesting LXA4 as a potential therapeutic target for age-related dementia.
bioRxiv · Nov 12, 2021 · PreprintNeuroscience