Isis Moraes Ornelas

Age-linked suppression of lipoxin A4 mediates cognitive deficits in mice and humans

This study shows that reduced lipoxin A4 levels in aging brains contribute to cognitive deficits in mice and humans, suggesting LXA4 as a potential therapeutic target for age-related dementia.

Non-permissive SARS-CoV-2 infection in human neurospheres

This study shows SARS-CoV-2 infection of human neural cells is non-permissive but causes inflammation and cell damage, suggesting neural damage in COVID-19 is due to systemic inflammation rather than direct viral replication.

Hyperoxia Inhibits the Growth of Mouse Forebrain Oligodendrocyte Progenitors

This study shows that low oxygen levels promote proliferation of mouse oligodendrocyte progenitors, unlike rat OPCs, and identifies factors affecting their differentiation.

Single-cell Sequencing Reveals Brain/Spinal Cord Oligodendrocyte Precursor Heterogeneity and Requirement for mTOR in Cholesterol Biosynthesis and Myelin Maintenance

The paper uses single-cell sequencing to show brain and spinal cord oligodendroglia are transcriptionally distinct, with mTOR playing a key role in cholesterol biosynthesis and myelin maintenance.

Short and long TNF-alpha exposure recapitulates canonical astrogliosis events in human induced pluripotent stem cells-derived astrocytes

This study shows that human iPSC-derived astrocytes exposed to TNF-alpha recapitulate key astrogliosis features over time, including cytokine secretion, morphological changes, and reduced aspartate uptake.

d-Lysergic acid diethylamide has major potential as a cognitive enhancer

This study shows that d-LSD enhances novel object preference in young and adult rats and can rescue this effect in old rats when combined with enriched environment exposure.