Bruna da Silveira Paulsen

This study shows that using human stem cell-derived ovarian support cells for in vitro maturation in mice leads to healthy live births without reprotoxic effects across generations.

The paper describes the development of a clinical-grade hiPSC-derived ovarian support cell protocol to improve in vitro maturation of oocytes and embryo formation.

This study shows that co-culturing human oocytes with ovarian support cells improves in vitro maturation rates and blastocyst formation compared to standard IVM methods.

This study shows that co-culturing immature human oocytes with hiPSC-derived ovarian support cells improves in vitro maturation rates and transcriptomic similarity to in vivo matured oocytes.

The paper investigates how PTEN heterozygous mutations affect different cell types in human cortical organoids and shows that these effects lead to abnormal circuit activity regardless of genetic background.

The paper presents a single-cell multiomics atlas of human cortical organoid development, revealing molecular programs of cellular diversification and identifying human-specific gene roles in lineage establishment.

This study shows that reduced lipoxin A4 levels in aging brains contribute to cognitive deficits in mice and humans, suggesting LXA4 as a potential therapeutic target for age-related dementia.

This study uses human brain organoids to show that ASD risk genes cause accelerated development of specific cortical neuron classes.