The proofreading mechanism of the human leading strand DNA polymerase ϵ holoenzyme
Feng Wang, Qing He, Mike E. O’Donnell, Huilin Li
This study uses cryo-EM to reveal the proofreading mechanism of the human Pol ε/PCNA holoenzyme, showing how mismatches are processed with PCNA's influence.
Proceedings of the National Academy of Sciences · May 29, 2025Peer-reviewedBiochemistry