Huilin Li

This study shows that ligand binding inhibits dimerization of the bacterial histidine kinase PdtaS, thereby repressing its activity and multi-ligand sensing.

This paper shows the E. coli DnaX clamp loader uses DNA bending instead of unwinding to load β-clamp at nicks and small gaps, revealing a distinct bacterial mechanism for DNA repair.

The paper identifies butyrolactol A as a compound that enhances caspofungin efficacy against resistant fungi by inhibiting phospholipid flippase, thereby improving antifungal treatment.

This study uses cryo-EM to reveal the proofreading mechanism of the human Pol ε/PCNA holoenzyme, showing how mismatches are processed with PCNA's influence.

This study investigates OMT formation in F. novicida using cryo-ET and microscopy, revealing envelope modifications and links to type VI secretion and phagosomal membrane changes.

This study identifies P4-ATPase Neo1's role in maintaining phosphoinositide membrane asymmetry and neomycin resistance by controlling extracellular PI4P exposure.

The paper reports a high-resolution cryo-EM structure of the mammalian 20S proteasome complex with PI31, revealing how PI31 inhibits proteasome activity.

The paper identifies sequence-specificity in DNA replication origins mediated by Orc4 α-helix in S. cerevisiae and links its evolution to gene silencing mechanisms.