Author

Casey O’Brien

Broad InstituteORCID 0000-0002-6572-4881Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Organism:human· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Alexis M. ThorntoniD· 1 shared Alice H. BergeriD· 1 shared Angela Norie BrooksiD· 1 shared April LoiD· 1 shared David HaaniD· 1 shared Lishan FangiD· 1 shared Maria V. McSharryiD· 1 shared Marios GiannakisiD· 1 shared

Activity by Year

2021-2021 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 28 mutual co-author links

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1 shared paperBioinformatics

Alexis M. ThorntonORCID

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1 paper

Recent·Most cited

eVIP2: Expression-based variant impact phenotyping to predict the function of gene variants

Alexis M. Thornton, Lishan Fang, April Lo, Maria V. McSharry, David Haan, Casey O’Brien, Alice H. Berger, Marios Giannakis, Angela Norie Brooks

The paper introduces eVIP2, a tool to predict the functional impact of gene variants using gene expression data, and validates its predictions with experimental assays.

PLoS Computational Biology · Jul 2, 2021Peer-reviewedBioinformatics