Author

Alexis M. Thornton

University of California, Santa CruzORCID 0000-0002-7987-2543Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Bioinformatics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:bulk RNA-seq· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Angela Norie BrooksiD· 2 shared Alice H. BergeriD· 1 shared Amit K. BeheraiD· 1 shared April LoiD· 1 shared Cameron M. SouletteiD· 1 shared Casey O’BrieniD· 1 shared Cindy E Liang· 1 shared Colette FeltoniD· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCancer Biology

Angela Norie BrooksORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

U2AF1 S34F enhances tumorigenic potential of lung cells by exhibiting synergy with KRAS mutation and altering response to environmental stress

Cindy E Liang, Eva Hrabeta‐Robinson, Selam Mehreteab, Amit K. Behera, Colette Felton, Isobel J. Fetter, Cameron M. Soulette, Alexis M. Thornton, Shaheen S. Sikandar, Angela Norie Brooks

This study shows U2AF1S34F enhances lung cell tumorigenicity when combined with KRAS mutations and environmental stress, altering splicing and stress responses.

bioRxiv · Sep 11, 2024 · PreprintCancer Biology

eVIP2: Expression-based variant impact phenotyping to predict the function of gene variants

Alexis M. Thornton, Lishan Fang, April Lo, Maria V. McSharry, David Haan, Casey O’Brien, Alice H. Berger, Marios Giannakis, Angela Norie Brooks

The paper introduces eVIP2, a tool to predict the functional impact of gene variants using gene expression data, and validates its predictions with experimental assays.

PLoS Computational Biology · Jul 2, 2021Peer-reviewedBioinformatics