Mary G Hirsch

ReDeNovo infers both known and novel mutational signatures from cancer genomes, outperforming existing methods and identifying new signatures in real data.

SpacePhenotyper transfers predictive gene expression-phenotype relationships from bulk data to spatial transcriptomics data to analyze clinical phenotypes in spatial regions of tumors.

The paper models gene expression adaptation in tumor subclones using stochastic processes and finds non-genetic mechanisms drive subclonal evolution and treatment response.