Ruben Duque do Vale

This paper identifies a cortico-collicular circuit in mice that encodes shelter direction and is essential for accurate orientation during escape.

This paper introduces a lightweight two-photon microscope for imaging over 1,000 neurons in freely moving mice, enabling large-scale calcium imaging with high resolution and minimal behavioral disruption.

The paper shows that escape decisions in mice are computed via a synaptic threshold mechanism involving mSC and dPAG neurons.

This study shows that mice can rapidly update their instinctive defensive behaviors based on spatial learning, switching strategies like escape to freezing when environments change.