Brainstem enkephalinergic neural circuit underlying cold-induced pain relief in mice
Hayun Kim, Yoon Kyung Lee, Seog Bae Oh
The paper identifies cold-responsive neurons in the lateral parabrachial nucleus that mediate cold-induced analgesia via enkephalin release in the ventrolateral periaqueductal gray.
bioRxiv · Nov 10, 2025 · PreprintNeuroscience