The cell cycle regulator Cyclin E1 drives macrophage-associated inflammatory responses in acute immune-mediated hepatitis
Christian Penners, Cheng Lin, Alexander Jans, Antje Mohs, Frank Tacke, Matthias Bartneck, Roland W. Sonntag, Christian Liedtke
This study shows Cyclin E1 promotes macrophage-driven inflammation in acute hepatitis, independent of cell cycle changes, by regulating IRF1 and NF-κB transcriptional programs.
bioRxiv · Oct 1, 2026 · PreprintCell Biology