Frank Tacke

This study shows Cyclin E1 promotes macrophage-driven inflammation in acute hepatitis, independent of cell cycle changes, by regulating IRF1 and NF-κB transcriptional programs.

This study shows that hepatocyte-specific mTORC2 deficiency slightly reduces liver disease from a choline-deficient diet, while myeloid cell deficiency has no effect.

This study introduces a medical training program with an application tunnel to reduce stress in mice during frequent intraperitoneal injections and blood sampling.

This paper introduces a tool to detect overlapping cells and segmentation errors in 3D spatial transcriptomics data.

The paper combines stem cell models and computational predictions to identify flavin cofactors as therapeutic targets for metabolic liver dysfunction.

This study uses multi-omics approaches to analyze how dietary restriction and sleeve gastrectomy affect the cellular and metabolic changes in steatotic livers in rats and humans.