Michel Charbonneau

A possible role for the kinetochore COMA complex in sensing the damage in stn1-sz2, a mutant of the Cdc13-Stn1-Ten1 telomeric complex

The paper investigates how the stn1-sz2 mutant of the CST complex causes mitotic-spindle-damage and identifies the COMA complex's role in sensing this damage through kinetochore interactions.

Dysfunction of telomeric Cdc13-Stn1-Ten1 simultaneously activates the DNA damage and spindle checkpoints

The paper identifies SIZ1 and TOP2 as suppressors of CST mutants in yeast, showing CST dysfunction activates DNA and spindle checkpoints through SUMOylation and mitotic spindle regulation.

The telomeric Cdc13-Stn1-Ten1 complex regulates RNA polymerase II transcription

This study identifies a novel role for the CST complex in regulating RNA polymerase II transcription by interacting with Spt5 and Hmo1, linking telomere maintenance to transcriptional processes.