Chao Yan

The paper performs single-cell transcriptome-wide association analysis to identify cell-type-specific genetic susceptibility genes for colorectal cancer, finding 546 gene-cell-type associations and 347 candidate susceptibility genes.

Adding OneK1K immune cell-type expression edges to an updated PrimeKG modestly improved drug-indication link prediction, AUPRC 0.816 to 0.826 overall and 0.847 to 0.864 for 40 autoimmune diseases.

The paper identifies genetic risk factors for hypertriglyceridemia in African ancestry populations using whole genome sequencing and electronic health records.