HIV Vpr activates a nucleolar-specific ATR pathway to degrade the nucleolar stress sensor CCDC137
Karly Nisson, Rishi S Patel, Yennifer Delgado, Mehdi Bouhaddou, Lucie Etienne, Oliver I. Fregoso
The paper shows HIV Vpr degrades CCDC137 via a nucleolar ATR pathway, causing nucleolar stress and ribosome biogenesis repression, independent of G2/M arrest.
Nucleic Acids Research · Jun 6, 2025Peer-reviewedMolecular Biology