Yennifer Delgado

The p53-p21-Cyclin D2 regulatory axis drives metabolic reprogramming and a distinct senescent macrophage senotype during aging and MASLD.

Multi-omics Reveals Divergent Endothelial Molecular Responses to New and Old World Hantaviruses

This study integrates multi-omics data to compare endothelial cell responses to New and Old World hantaviruses, identifying species-specific immune and cellular mechanisms.

SARS-CoV-2 nucleocapsid induces hyperinflammation and vascular leakage through the Toll-like receptor signaling axis in macrophages

This study shows the SARS-CoV-2 nucleocapsid protein drives hyperinflammation and vascular leakage in macrophages via Toll-like receptor signaling, contributing to severe COVID-19 complications.

Paracrine Signals from HIV-1 Infected Immune Cells Reprogram Cervical Cancer Pathways

This study shows HIV-1 infected immune cells alter cervical cancer pathways through paracrine signals, with upregulated PI3K-AKT and interferon-stimulated genes.

HIV-1 latency reversing agents converge on phosphoregulation of nuclear protein complexes

This study identifies phosphoregulation of nuclear protein complexes by HIV-1 latency-reversing agents, revealing shared mechanisms across different LRAs.

HIV Vpr activates a nucleolar-specific ATR pathway to degrade the nucleolar stress sensor CCDC137

The paper shows HIV Vpr degrades CCDC137 via a nucleolar ATR pathway, causing nucleolar stress and ribosome biogenesis repression, independent of G2/M arrest.

Global Landscape of Human Kinase Motifs in Viral Proteomes

The paper identifies human kinase motifs in viral proteomes, showing enrichment for stress and immune-related kinases and their phosphorylation in infected cells.

Drug screen reveals new potent host-targeted antivirals against Mpox virus

The paper identifies potent host-targeted antivirals against Mpox virus through high-throughput screening of a kinase inhibitor library, showing efficacy in vitro and in a mouse model.

The Chlamydia trachomatis secreted effector CebN targets nucleoporins and Rae1 to antagonize STAT1 nuclear import

This study identifies CebN, a Chlamydia trachomatis effector that targets nucleoporins and Rae1 to disrupt STAT1 nuclear import, aiding bacterial survival.