BiochemistrybioRxivPreprint
Chemoproteomics discovery of a CNS-penetrant covalent inhibitor of PIKfyve
Antony J. Burton, Louis S. Chupak, Alison J Davis…·Elayne Chan-Penebre
This paper discovers and optimizes a CNS-penetrant covalent inhibitor of PIKfyve, DUN058, showing sustained target occupancy and modulation of protein clearance pathways in vivo.
DOI 10.64898/2026.01.26.701341