Genome-wide functional screens enable the prediction of high activity CRISPR-Cas9 and -Cas12a guides in Yarrowia lipolytica
Dipankar Ranjan Baisya, Adithya Ramesh, Cory Schwartz, Stefano Lonardi, Ian R. Wheeldon
The paper develops DeepGuide, a deep learning model to predict high activity CRISPR-Cas9 and -Cas12a guides in Yarrowia lipolytica using genome-wide functional screens.
Nature Communications · Feb 17, 2022Peer-reviewedSynthetic Biology