scKAN: Interpretable Single-cell Analysis for Cell-type-specific Gene Discovery and Drug Repurposing via Kolmogorov-Arnold Networks
Haohuai He, Zhenchao Tang, Guanxing Chen, Fan Xu, Yao Fei Hu, Yinglan Feng, Jibin Wu, Yu‐An Huang, Zhi-An Huang, Kay Chen Tan
scKAN improves cell-type annotation and marker gene discovery using Kolmogorov-Arnold Networks, achieving a 6.63% higher macro F1 score than existing methods and identifying potential drug repurposing candidates.
Genome biology · Sep 24, 2025Peer-reviewedBioinformatics