Author

Guanxing Chen

Sun Yat-sen UniversityORCID 0000-0002-4435-0884Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Assay:scRNA-seq· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Organism:human· 1 Approach:large language model· 1 Assay:protein sequence· 1

Frequent Co-Authors

Haohuai HeiD· 3 shared Calvin Yu‐Chian CheniD· 2 shared Zhenchao TangiD· 2 shared Bing HeiD· 1 shared Fan XuiD· 1 shared Jianhua YaoiD· 1 shared Jibin WuiD· 1 shared Jiehui HuangiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersBioinformatics

Haohuai HeORCID

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3 papers

Recent·Most cited

scProtoTransformer: Scalable Reference Mapping Across Molecules, Cells and Donors

Zhenchao Tang, Haohuai He, Shouzhi Chen, Jun Zhu, Tianxu Lv, Zhou Jiale, Jiehui Huang, Yaokun Li, Guanxing Chen, Linlin You, Calvin Yu‐Chian Chen

scProtoTransformer provides a scalable reference mapping framework across molecular, cellular, and donor levels using a prototype-based Transformer model with improved interpretability and performance.

Science Advances · Aug 28, 2026Peer-reviewedBioinformatics

scKAN: Interpretable Single-cell Analysis for Cell-type-specific Gene Discovery and Drug Repurposing via Kolmogorov-Arnold Networks

Haohuai He, Zhenchao Tang, Guanxing Chen, Fan Xu, Yao Fei Hu, Yinglan Feng, Jibin Wu, Yu‐An Huang, Zhi-An Huang, Kay Chen Tan

scKAN improves cell-type annotation and marker gene discovery using Kolmogorov-Arnold Networks, achieving a 6.63% higher macro F1 score than existing methods and identifying potential drug repurposing candidates.

Genome biology · Sep 24, 2025Peer-reviewedBioinformatics

De novo generation of antibody CDRH3 with a pre-trained generative large language model

Haohuai He, Bing He, Lei Guan, Yu Shan Zhao, Guanxing Chen, Qing-Ge Zhu, Calvin Yu‐Chian Chen, Ting Li, Jianhua Yao

This paper introduces PALM, a pre-trained generative large language model for de novo antibody CDRH3 design, and A2binder for predicting antigen-antibody binding, showing effectiveness against SARS-CoV-2 variants.

bioRxiv · Oct 17, 2023 · PreprintBioinformatics