Author

Wayne A. Fenton

Yale UniversityORCID 0000-0002-6804-8401Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Arthur L. HorwichiD· 3 shared Maria Nagy· 3 shared Eleanor V. ThomasiD· 1 shared Hongyu ZhaoiD· 1 shared Justin L. CotneyiD· 1 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 8 mutual co-author links

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3 shared papersNeuroscience

Arthur L. HorwichORCID

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3 papers

Recent·Most cited

Neuronal overexpression of mouse potassium channel subunit Kcnn1 in A53T α-synuclein mice more than doubles median survival time, associated with suppression of phospho-S129 α-synuclein formation

Maria Nagy, Wayne A. Fenton, Arthur L. Horwich

This study shows that overexpressing Kcnn1 in A53T α-synuclein mice significantly increases survival and reduces phospho-S129 α-synuclein accumulation.

bioRxiv · Mar 18, 2026 · PreprintNeuroscience

Neuronal overexpression of potassium channel subunit Kcnn1 prolongs survival of SOD1-linked ALS and A53T alpha-synuclein mouse models

Maria Nagy, Justin L. Cotney, Wayne A. Fenton, Arthur L. Horwich

This study shows that overexpressing the potassium channel subunit Kcnn1 in ALS and alpha-synuclein mouse models extends survival and reduces protein aggregation by inducing stress response pathways.

bioRxiv · Oct 11, 2024 · PreprintNeuroscience

Motor nuclei innervating eye muscles spared in mouse model of SOD1-linked ALS

Eleanor V. Thomas, Maria Nagy, Hongyu Zhao, Wayne A. Fenton, Arthur L. Horwich

The paper shows that cranial nerve motor nuclei innervating eye muscles are spared in a mouse model of SOD1-linked ALS, mirroring human ALS patterns.

bioRxiv · Oct 24, 2018 · PreprintNeuroscience