Athina Gavriilidou

PanBGC provides a framework to analyze biosynthetic gene clusters across microbial genomes, classifying genes into core, accessory, and unique categories and quantifying diversity through openness metrics.

Goldfinder infers gene co-occurrence and co-avoidance in bacterial pangenomes by considering phylogenetic relationships, reducing spurious associations compared to existing tools.

The paper reclassifies glycopeptide antibiotics as xyclopeptides based on structural and evolutionary analyses of biosynthetic gene clusters.

The paper analyzes bacterial genomes and metagenome assembled genomes to assess the diversity of secondary metabolite biosynthesis, finding that only 3% of potential natural products are experimentally characterized.