Stefano Pascarella

Genome-based comparison between the recombinant SARS-CoV-2 XBB and its parental lineages

This study compares the genome of the SARS-CoV-2 XBB recombinant with its parental lineages, finding no significant expansion capability or danger.

Genetic and structural data on the SARS-CoV-2 Omicron BQ.1 variant reveal its low potential for epidemiological expansion

The paper analyzes the genetic and structural features of the SARS-CoV-2 BQ.1 variant to assess its potential for epidemiological expansion and finds it lacks significant evolutionary diversification and immune escape capabilities compared to BA.5.

The evolution of Monkeypox virus: a genetic and structural analysis reveals mutations in proteins involved in host-pathogen interaction

This study analyzes mutations in the Monkeypox virus during the 2022 outbreak, identifying six new mutations and their potential impact on host-pathogen interactions and viral fitness.

Cutting epitopes to survive: the case of lambda variant

This study investigates how Spike protein mutations in the SARS-CoV-2 lambda variant may enhance immuno-escape through epitope shortening and N-glycosylation site generation.

SARS-CoV-2 B.1.617 Indian variants: are electrostatic potential changes responsible for a higher transmission rate?

The paper investigates whether electrostatic potential changes in the B.1.617 SARS-CoV-2 variant's spike protein RBD contribute to increased transmission by enhancing interaction with ACE2.

Long-chain polyphosphates impair SARS-CoV-2 infection and replication: a route for therapy in man

The paper investigates the anti-viral effects of long-chain polyphosphates (PolyPs) against SARS-CoV-2, showing they impair infection and replication by interacting with ACE2 and RdRp.