bioRxivBioinformaticsPreprint
Cutting epitopes to survive: the case of lambda variant
Stefano PascarellaiD, Massimo CiccozziiD, Martina BianchiiD, Domenico BenvenutoiD, Roberto CaudaiD, Antonio CassoneiD
Abstract
This manuscript concisely reports an in-silico study on the potential impact of the Spike protein mutations on immuno-escape ability of SARS-CoV-2 lambda variant. Biophysical and bioinformatics data suggest that a combination of shortening immunogenic epitope loops and generation of potential N-glycosylation sites may be a viable adaptation strategy potentially allowing this emerging viral variant escaping host immunity.
- assay: protein sequence
- research focus: variant effect prediction
- approach: statistical model
- approach: simulation
- Citations
- 0
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