Pyridoxal Kinase Inhibition by Artemisinins Downregulates Inhibitory Neurotransmission
Vikram Babu Kasaragod, Anabel Pacios-Michelena, Natascha Schaefer, Fang Zheng, Nicole Bader, Christian Alzheimer, Carmen Villmann, Hermann Schindelin
This study shows artemisinins inhibit pyridoxal kinase, disrupting GABAergic signaling by reducing PLP production and affecting glutamic acid decarboxylase activity.
Proceedings of the National Academy of Sciences · Dec 14, 2020Peer-reviewedNeuroscience