BioengineeringbioRxivPreprint
Reversal of contractile defects by mediating calcium homeostasis in human mini-heart models of heart failure with preserved ejection fraction (HFpEF) leads to first-in-human gene therapy clinical trial
Kevin D. Costa, Andy O.-T. Wong, Suet Yee Mak…·Ronald A. Li
This paper develops human mini-heart models of HFpEF, identifies SERCA2a downregulation, and demonstrates gene therapy efficacy, leading to a first-in-human clinical trial.
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